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doi: 10.1016/j.colsurfb.2017.07.027 543 BarchittaMMaugeriAFavaraGMagnano San LioREvolaGAgodiAet al

Notably, a BH 4 deficiency lowers the glutathione (GSH)/glutathione disulfide (GSSG) redox ratio, promotes eNOS S-glutathionylation, and further impairs NO production, thereby contributing to endothelial dysfunction and vascular inflammation with aging [141, 142]